Chemical Structure : DSHN-OMe
CAS No.:
DSHN-OMe
(DSHN methyl ester)
Catalog No.: PC-21099Not For Human Use, Lab Use Only.
DSHN-OMe (DSHN methyl ester) is a small molecule modulator of NR0B2, effectively reduces induction of LXR target gene ABCA1 by GW3965 (1 uM) in BMDMs with IC50 of 3.8 uM, reduces regulatory T cell expansion and impede breast cancer progression.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DSHN-OMe (DSHN methyl ester) is a small molecule modulator of NR0B2, effectively reduces induction of LXR target gene ABCA1 by GW3965 (1 uM) in BMDMs with IC50 of 3.8 uM, reduces regulatory T cell expansion and impede breast cancer progression.
DSHN-OMe significantly reduced the outgrowth of established 4T1 metastatic lesions as a single agent.
DSHN-OMe also significantly reduced metastatic burden in mice grafted with EMT6 cells, an alternative murine mammary cancer model.
DSHN-OMe decreased FOXP3 expression in EMT6 metastatic lungs models.
NR0B2 is a protein involved in cholesterol homeostasis, functions within myeloid immune cells to modulate the NLRP3 inflammasome and reduce the expansion of immune-suppressive regulatory T cells (Treg).
Physicochemical Properties
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M.Wt
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337.39
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Formula
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C16H19NO5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl 5-(N,N-diethylsulfamoyl)-3-hydroxy-2-naphthoate
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References
1. Hashni Epa Vidana Gamage, et al. bioRxiv. 2023 Aug 14;2023.08.14.553229.
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