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Chemical Structure : DSHN-OMe
Catalog No.: PC-21099Not For Human Use, Lab Use Only.
DSHN-OMe (DSHN methyl ester) is a small molecule modulator of NR0B2, effectively reduces induction of LXR target gene ABCA1 by GW3965 (1 uM) in BMDMs with IC50 of 3.8 uM, reduces regulatory T cell expansion and impede breast cancer progression.
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DSHN-OMe (DSHN methyl ester) is a small molecule modulator of NR0B2, effectively reduces induction of LXR target gene ABCA1 by GW3965 (1 uM) in BMDMs with IC50 of 3.8 uM, reduces regulatory T cell expansion and impede breast cancer progression.
DSHN-OMe significantly reduced the outgrowth of established 4T1 metastatic lesions as a single agent.
DSHN-OMe also significantly reduced metastatic burden in mice grafted with EMT6 cells, an alternative murine mammary cancer model.
DSHN-OMe decreased FOXP3 expression in EMT6 metastatic lungs models.
NR0B2 is a protein involved in cholesterol homeostasis, functions within myeloid immune cells to modulate the NLRP3 inflammasome and reduce the expansion of immune-suppressive regulatory T cells (Treg).
| M.Wt | 337.39 | |
| Formula | C16H19NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hashni Epa Vidana Gamage, et al. bioRxiv. 2023 Aug 14;2023.08.14.553229.
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