Chemical Structure : 164B8
CAS No.:
3101950-55-1
164B8
Catalog No.: PC-26206Not For Human Use, Lab Use Only.
164B8 is a highly potent, covalent Pin1 inhibitor / degrader with IC50 of 4.65 nM, reacts with the Pin1 active-site residue Cys113, effectively induces Pin1 degradation both in cell and in vivo.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
164B8 is a highly potent, covalent Pin1 inhibitor / degrader with IC50 of 4.65 nM, reacts with the Pin1 active-site residue Cys113, effectively induces Pin1 degradation both in cell and in vivo.
164B8 (5 uM) induces duration of Pin1 degradation approximately 50% after 48 h in BxPC3 and KPC cells.
164B8 inhibits cell viability of MIA PaCa-2 cells and KPC cell lines with EC50 of 8.4 uM and 5.3 uM respectively.
164B8 (30 mg/kg, 60 mg/kg) caused significant, dose-dependent reduction in tumor burden in murine model of metastatic pancreatic cancer.
Physicochemical Properties
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M.Wt
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625.55
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Formula
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C31H34Cl2N6O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-((S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-1-((S)-3-(6-chloro-1H-indol-3-yl)-2-(2-chloroacetamido)propanoyl)piperidine-2-carboxamide
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References
1. Giulia Alboreggia, et al. Mol Ther Oncol. 2025 Nov 1;33(4):201078.
2. Patent US20250296955 A1.
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