Furin inhibitor 27

Chemical Structure : Furin inhibitor 27

Catalog No.: PC-26215Not For Human Use, Lab Use Only.

Furin inhibitor 27 is a highly potent, small molecule inhibitor of proprotein convertase (PC) furin with Ki of 1.67 nM, also inhibits the structurally related PC7 with Ki of 7.27 nM.

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Biological Activity

Furin inhibitor 27 is a highly potent, small molecule inhibitor of proprotein convertase (PC) furin with Ki of 1.67 nM, also inhibits the structurally related PC7 with Ki of 7.27 nM.

Physicochemical Properties

M.Wt	566.57
Formula	C31H37Cl2N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1-((3',5'-Dichloro-5-((4-(pyridin-4-yl)-piperazin-1-yl)-methyl)-[1,1'-biphenyl]-3-yl)-methyl)-piperidin-4-yl)-methyl)-acetamide

References

1. Lange RW, et al. J Med Chem. 2025 Nov 30. doi: 10.1021/acs.jmedchem.5c02157.

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