TREM2 activator 4a

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Chemical Structure : TREM2 activator 4a

Catalog No.: PC-24791Not For Human Use, Lab Use Only.

TREM2 activator 4a is a specific small molecule activator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 12.7 uM, 1.5-fold selectivity over TREM1, induces SYK phosphorylation and significantly enhances microglial phagocytic activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	468.66
Formula	C27H36N2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-methoxy-N-methyl-3-(3-methylenecyclobutane-1-carboxamido)-5-(3-octylthiophen-2-yl)benzamide

References

1. Hossam Nada, et al. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.

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