Chemical Structure : TREM2 activator 4i
CAS No.:
TREM2 activator 4i
(TREM2 agonist)
Catalog No.: PC-24790Not For Human Use, Lab Use Only.
TREM2 activator 4i is a specific small molecule activator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 19.0 uM in MST assays, 2-fold selectivity over TREM1, induces SYK phosphorylation and significantly enhances microglial phagocytic activity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TREM2 activator 4i is a specific small molecule activator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 19.0 uM in MST assays, 2-fold selectivity over TREM1, induces SYK phosphorylation and significantly enhances microglial phagocytic activity.
TREM2 is a thyroid hormone-regulated gene and its expression in macrophages and microglia is stimulated by thyroid hormone and synthetic thyroid hormone agonists (thyromimetics).
Physicochemical Properties
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M.Wt
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398.48
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Formula
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C21H22N2O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(5-acetylthiophen-2-yl)-4-methoxy-N-methyl-5-(3-methylenecyclobutane-1-carboxamido)benzamide
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References
1. Hossam Nada, et al. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.
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