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NGI-190

Chemical Structure : NGI-190

CAS No.: 2763063-58-5

NGI-190 (NGI190, NGI 190)

Catalog No.: PC-24838Not For Human Use, Lab Use Only.

NGI-190 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.59 uM.

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    Biological Activity

    NGI-190 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.59 uM.
    NGI-190 demonstrates activity against both OST-A and OST-B, with preferential inhibition of OST-B.

    Physicochemical Properties

    M.Wt 486.55
    Formula C20H24F2N4O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(3,3-difluoropyrrolidin-1-yl)-N-(5-ethylthiazol-2-yl)-5-(morpholinosulfonyl)benzamide

    References

    1. Baro M, et al. Cell Chem Biol. 2025 Jun 19;32(6):839-853.e6.

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