NGI-190

Chemical Structure : NGI-190

Catalog No.: PC-24838Not For Human Use, Lab Use Only.

NGI-190 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.59 uM.

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Biological Activity

NGI-190 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.59 uM.
NGI-190 demonstrates activity against both OST-A and OST-B, with preferential inhibition of OST-B.

Physicochemical Properties

M.Wt	486.55
Formula	C20H24F2N4O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,3-difluoropyrrolidin-1-yl)-N-(5-ethylthiazol-2-yl)-5-(morpholinosulfonyl)benzamide

References

1. Baro M, et al. Cell Chem Biol. 2025 Jun 19;32(6):839-853.e6.

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NGI-190

Biological Activity

Physicochemical Properties

References

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