Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-SID7969543
SID7969543

Chemical Structure : SID7969543

CAS No.: 868224-64-0

SID7969543 (SID 7969543)

Catalog No.: PC-72819Not For Human Use, Lab Use Only.

SID7969543 is a potent, selective and cell penetrant inhibitor of steroidogenic factor 1 (SF-1/NR5A1) with IC50 of 760 nM, also selectively targets KMT2A-rearranged (KMT2A-r) leukemia cells.

Packing Price Stock Quantity
5 mg $228 In stock
10 mg $378 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SID7969543 is a potent, selective and cell penetrant inhibitor of steroidogenic factor 1 (SF-1/NR5A1) with IC50 of 760 nM, also selectively targets KMT2A-rearranged (KMT2A-r) leukemia cells.
SID7969543 limited the viability of 7 out of 11 KMT2A-r leukemia cell lines including 5 out of 7 lines derived from infants, without affecting KMT2A-wt leukemia cells, solid cancer lines, non-malignant cell lines, or peripheral blood mononuclear cells from healthy controls.
SID7969543 decreased KMT2A-r leukemia cell viability by inducing caspase-dependent apoptosis within hours of treatment and demonstrated synergy with established chemotherapeutics used in the treatment of high-risk leukemia.

Physicochemical Properties

M.Wt 452.46
Formula C24H24N2O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethyl2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate

References

1. Madoux F, et al. Mol Pharmacol. 2008 Jun;73(6):1776-84.

2. Karsa M, et al. Front Oncol. 2022 Jan 20;11:779859.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: