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PDDC

Chemical Structure : PDDC

CAS No.: 2232878-43-0

PDDC (nSMase2 inhibitor PDDC)

Catalog No.: PC-72748Not For Human Use, Lab Use Only.

PDDC is the first potent, selective, orally-available, and brain-penetrable nSMase2 (neutral sphingomyelinase 2) inhibitor with pIC50 of 6.57.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PDDC is the first potent, selective, orally-available, and brain-penetrable nSMase2 (neutral sphingomyelinase 2) inhibitor with pIC50 of 6.57.
PDDC inhibited release of ADEVs in tissue culture and in vivo, capable of dose-dependently reducing EVs release in vitro and in vivo.
PDDC reduced these IL-1β-induced changes implicating nSMase2 inhibition as a therapeutic target for acute brain injury.

Physicochemical Properties

M.Wt 487.56
Formula C27H29N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl)carbamate

References

1. Rojas C, et al. Br J Pharmacol. 2019 Oct;176(19):3857-3870.

2. Šála M, et al. J Med Chem. 2020 Jun 11;63(11):6028-6056.

3. Tallon C, et al. Biochem Pharmacol. 2021 Dec;194:114796.

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