Catalog No.: PC-72788Not For Human Use, Lab Use Only.
S62798 (S 62798) is a highly selective human, mouse and rat TAFIa (Thrombin Activatable Fibrinolysis Inhibitor) inhibitor with IC50 of 11, 270, 178 nM respectively.
S62798 (S 62798) is a highly selective human, mouse and rat TAFIa (Thrombin Activatable Fibrinolysis Inhibitor) inhibitor with IC50 of 11, 270, 178 nM respectively.
S62798 accelerates lysis of a human clot in vitro, evaluated by thromboelastometry (EC50=27 nM).
In a rat tail bleeding model, no effect of S62798 treatment was observed up to 20 mg/kg.
Enhancement of endogenous fibrinolysis by S62798 was investigated in a mouse model of Tissue Factor-induced pulmonary thromboembolism.
Intravenous administration of S62798 decreased pulmonary fibrin clots with a minimal effective dose of 0.03 mg/kg.
