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Chemical Structure : S62798
Catalog No.: PC-72788Not For Human Use, Lab Use Only.
S62798 (S 62798) is a highly selective human, mouse and rat TAFIa (Thrombin Activatable Fibrinolysis Inhibitor) inhibitor with IC50 of 11, 270, 178 nM respectively.
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S62798 (S 62798) is a highly selective human, mouse and rat TAFIa (Thrombin Activatable Fibrinolysis Inhibitor) inhibitor with IC50 of 11, 270, 178 nM respectively.
S62798 accelerates lysis of a human clot in vitro, evaluated by thromboelastometry (EC50=27 nM).
In a rat tail bleeding model, no effect of S62798 treatment was observed up to 20 mg/kg.
Enhancement of endogenous fibrinolysis by S62798 was investigated in a mouse model of Tissue Factor-induced pulmonary thromboembolism.
Intravenous administration of S62798 decreased pulmonary fibrin clots with a minimal effective dose of 0.03 mg/kg.
| M.Wt | 438.4402 | |
| Formula | C20H28FN4O4P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sansilvestri-Morel P, et al. Thromb Res. 2021 Aug;204:81-87.
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