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Chemical Structure : DC-SX029
CAS No.: 300713-88-6
Catalog No.: PC-72765Not For Human Use, Lab Use Only.
DC-SX029 is a new small-molecule sorting nexin 10 (SNX10) inhibitor (KD=0.935 uM), blocks the SNX10-PIKfyve interaction, decreases TBK1/c-Rel signaling activation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $198 | In stock | |
| 5 mg | $348 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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DC-SX029 is a new small-molecule sorting nexin 10 (SNX10) inhibitor (KD=0.935 uM), blocks the SNX10-PIKfyve interaction, decreases TBK1/c-Rel signaling activation.
DC-SX029 reduced inflammatory response by inhibiting PIKfyve-mediated TBK1/c-Rel signal activation in BMDMs, inhibited mRNA levels of proinflammatory cytokines IL12/23 with IC50 of 18.6 uM.
DC-SX029 alleviated DSS-induced mouse colitis, improved IL-10-deficient mouse colitis.
| M.Wt | 398.353 | |
| Formula | C14H17F3N2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,5,5-trifluoro-4-(((4-((methoxycarbonyl)amino)phenyl)sulfonamido)methyl)pentanoic acid |
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1. Weilian Bao, et al. Pharmacol Res. 2021 Jul;169:105679.
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