Nek1 inhibitor 10f

Chemical Structure : Nek1 inhibitor 10f

Catalog No.: PC-72831Not For Human Use, Lab Use Only.

Nek1 inhibitor 10f is a potent, selective NIMA-related kinase 1 (Nek1) inhibitor with IC50 of 330 nM.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Nek1 inhibitor 10f is a potent, selective NIMA-related kinase 1 (Nek1) inhibitor with IC50 of 330 nM.
Nek1 inhibitor 10f displayed insignificant inhibition in 48 of 50 kinases in a selectivity test panel.
Nek1 has lately garnered attention for its widespread function in ciliogenesis, apoptosis, and the DNA-damage response.
Administration of Nek1 inhibitor 10f caused the expansion of fluorescence-labeled proximal convoluted tubules. Nek1-inhibition causes cystic kidneys in zebrafish embryos of zebrafish polycystic kidney disease model.

Physicochemical Properties

M.Wt	446.525
Formula	C24H22N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide

References

1. Georg Baumann, et al. J Med Chem. 2022 Jan 27;65(2):1265-1282.