You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-CVN424
CVN424

Chemical Structure : CVN424

CAS No.: 2254706-21-1

CVN424 (CVN-424, CVN 424)

Catalog No.: PC-72762Not For Human Use, Lab Use Only.

CVN424 (CVN 424) is a highly potent, selective, brain-penetrant, orally active GPR6 inverse agonist with EC50 of 38 nM.

Packing Price Stock Quantity
5 mg $228 In stock
25 mg $528 In stock
100 mg Get quote
250 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CVN424 (CVN 424) is a highly potent, selective, brain-penetrant, orally active GPR6 inverse agonist with EC50 of 38 nM.
Oral administration of CVN424 dose-dependently increases locomotor activity and reverses haloperidol-induced catalepsy.
CVN424 restored mobility in bilateral 6-hydroxydopamine lesion model of Parkinson disease.
CVN424 is brain-penetrant and shows dose-dependent receptor occupancy that attained brain 50% of receptor occupancy at plasma concentrations of 6.0 and 7.4 ng/ml in mice and rats, respectively.
CVN424 is effective in preclinical models and is a potential therapeutic for improving motor function in patients with Parkinson disease.

Physicochemical Properties

M.Wt 473.525
Formula C24H29F2N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-1-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-((tetrahydrofuran-3-yl)amino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethan-1-one

References

1. Brice NL, et al. J Pharmacol Exp Ther. 2021 Jun;377(3):407-416.

2. M, Green J, et al. J Med Chem. 2021 Jul 22;64(14):9875-9890.

3. Margolin DH, et al. J Pharmacol Exp Ther. 2022 Feb 2:JPET-AR-2021-000842. 

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: