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Chemical Structure : Ternatin-4
Catalog No.: PC-22060Not For Human Use, Lab Use Only.
Ternatin-4 is a small molecule elongation factor-1alpha (eEF1A) inhibitor, triggers the ubiquitination and degradation of eEF1A on stalled ribosomes, targets the complex of eEF1A bound to aminoacyl-tRNAs (aa-tRNA).
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Ternatin-4 is a small molecule elongation factor-1alpha (eEF1A) inhibitor, triggers the ubiquitination and degradation of eEF1A on stalled ribosomes, targets the complex of eEF1A bound to aminoacyl-tRNAs (aa-tRNA).
Ternatin-4 stalls elongation by preventing aa-tRNA release from eEF1A on the ribosome.
Ternatin-4 promotes eEF1A degradation in a manner that requires translating ribosomes.
Ternatin-4 promotes RNF14 and RNF25-dependent ubiquitination of eEF1A and ribosomal proteins.
| M.Wt | 776.03 | |
| Formula | C40H69N7O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Oltion K, et al. Cell. 2023 Jan 19;186(2):346-362.e17.
2. Juette MF, et al. Elife. 2022 Oct 20;11:e81608.
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