Ternatin-4

Chemical Structure : Ternatin-4

Catalog No.: PC-22060Not For Human Use, Lab Use Only.

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Biological Activity

Ternatin-4 is a small molecule elongation factor-1alpha (eEF1A) inhibitor, triggers the ubiquitination and degradation of eEF1A on stalled ribosomes, targets the complex of eEF1A bound to aminoacyl-tRNAs (aa-tRNA).
Ternatin-4 stalls elongation by preventing aa-tRNA release from eEF1A on the ribosome.
Ternatin-4 promotes eEF1A degradation in a manner that requires translating ribosomes.
Ternatin-4 promotes RNF14 and RNF25-dependent ubiquitination of eEF1A and ribosomal proteins.

Physicochemical Properties

M.Wt	776.03
Formula	C40H69N7O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(9S,12S,15S,18S,24aR)-6-((S)-sec-butyl)-3-((R)-1-hydroxy-2-methylpropyl)-12-isobutyl-8,9,11,17,18-pentamethyl-15-((R)-2-methylbut-3-en-1-yl)hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptaone

References

1. Oltion K, et al. Cell. 2023 Jan 19;186(2):346-362.e17.

2. Juette MF, et al. Elife. 2022 Oct 20;11:e81608.

Ternatin-4

Biological Activity

Physicochemical Properties

References

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