MAGMAS inhibitor BT9

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Chemical Structure : MAGMAS inhibitor BT9

Catalog No.: PC-21924Not For Human Use, Lab Use Only.

MAGMAS inhibitor BT9 is a small molecule MAGMAS (mitochondria associated, granulocyte-macrophage colony stimulating factor signaling molecule) inhibitor with binding Kd of 33 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MAGMAS inhibitor BT9 is a small molecule MAGMAS (mitochondria associated, granulocyte-macrophage colony stimulating factor signaling molecule) inhibitor with binding Kd of 33 uM.
MAGMAS inhibitor BT9 inhibits growth at the 4 μM scale in yeast proliferation assays.
MAGMAS inhibitor BT9 decreases cell proliferation, migration, and oxidative phosphorylation in adult glioblastoma cell lines (DAOY cell, 24hrs IC50: 3.6uM; D425 cells, 24hrs IC50: 3.4uM).

Physicochemical Properties

M.Wt	325.46
Formula	C20H27N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-carbamimidoyl-4-((3-ethyl-2,4,4-trimethylcyclohex-2-en-1-ylidene)methyl)benzamide

References

1. Zahra Motahari, et al. bioRxiv. 2024 Mar 3:2024.02.29.582709.

2. Paul T Jubinsky, et al. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3479-82.

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