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Epoxykynin

Chemical Structure : Epoxykynin

CAS No.: 640263-95-2

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Epoxykynin

Catalog No.: PC-21923Not For Human Use, Lab Use Only.

Epoxykynin is a potent, selective  soluble epoxide hydrolase (sEH) with IC50 of 36 nM, inhibits the hydrolase activity of sEH and modulates kynurenine pathway.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Epoxykynin is a potent, selective  soluble epoxide hydrolase (sEH) with IC50 of 36 nM, inhibits the hydrolase activity of sEH and modulates kynurenine pathway.
potently inhibits kynurenine (Kyn) production with IC50 of 13.0 nM in IFN-γ-stimulated HeLa cells.
does not inhibit phosphatase activity of sEH and not affect the in vitro enzymatic activity of IDO1.
Epoxykynin inhibits the hydrolase activity of purified sEH very potently with IC50 of 6.7 nM.
Epoxykynin reduces Kyn levels in cells expressing IDO1.

Physicochemical Properties

M.Wt 445.28
Formula C19H20BrF3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(5-bromo-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl)-N-cycloheptylacetamide

References

1. Lara Dötsch, et al. J Med Chem. 2024 Mar 12. doi: 10.1021/acs.jmedchem.3c02245.

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