Chemical Structure : AZ9567
CAS No.:
2778235-14-4
AZ9567
(AZ'9567, AZ 9567)
Catalog No.: PC-21926Not For Human Use, Lab Use Only.
AZ9567 is a potent, selective methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 1 nM, selectively targets MTAP-deficient cancer cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AZ9567 is a potent, selective methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 1 nM, selectively targets MTAP-deficient cancer cells.
AZ9567 demonstrates potent cellular inhibition of MAT2a-driven SAM synthesis in the engineered HCT116 MTAP knockout (KO) model with pIC50 of 8.6.
AZ9567 displays preferential sensitivity in MTAP KO HCT116 compared to isogenic parental HCT116 for SDMA and growth inhibition.
AZ9567 exhibits selective antiproliferative activity toward MTAP-null lymphoma, lung, and pancreatic cancer cell lines.
AZ9567 (20 mg/kg BID) shows robust antitumor response in MTAP KO HCT116 xenograft model.
Physicochemical Properties
|
M.Wt
|
447.45
|
|
Formula
|
C24H19F2N5O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
3-Cyclopropyl-4-(4-(difluoromethoxy)phenyl)-6-(2-methyl-2H-indazol-5-yl)-1,4-dihydro-5H-pyrazolo[4,3-b]pyridin-5-one
|
References
1. Atkinson SJ, et al. J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c01860.
Contact Us
sales@probechem.com
