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EBP inhibitor 11

Chemical Structure : EBP inhibitor 11

CAS No.:

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EBP inhibitor 11

Catalog No.: PC-21945Not For Human Use, Lab Use Only.

EBP inhibitor 11 is a potent, selective, brain-penetrant, orally bioavailable inhibitor of emopamil binding protein (EBP) with mGCMS zymo EC50 of 8 nM, and OPC differentiation EC50 of 44 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

EBP inhibitor 11 is a potent, selective, brain-penetrant, orally bioavailable inhibitor of emopamil binding protein (EBP) with mGCMS zymo EC50 of 8 nM, and OPC differentiation EC50 of 44 nM.
EBP inhibitor 11 exhibits EC50 of 39 nM in hGCMS cellular assays.
EBP inhibitor 11 demonstrates strong in vivo target engagement in the brain, as illustrated by the accumulation of EBP substrate zymostenol after repeated dosing.

Physicochemical Properties

M.Wt 411.55
Formula C24H33N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-Cyclopropylphenyl)-1-ethyl-8-((tetrahydro-2H-pyran-4-yl)methyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione

References

1. Ruth Dorel, et al. J Med Chem. 2024 Mar 12. doi: 10.1021/acs.jmedchem.3c02396.

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