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BAY-069

Chemical Structure : BAY-069

CAS No.: 2639638-66-5

BAY-069 (BAY069)

Catalog No.: PC-49389Not For Human Use, Lab Use Only.

BAY-069 (BAY069) is a potent, selective branched-chain amino acid transaminase BCAT1/2 inhibitor with IC50 of 31/153 nM, respectively.

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5 mg $358 In stock
10 mg $548 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAY-069 (BAY069) is a potent, selective branched-chain amino acid transaminase BCAT1/2 inhibitor with IC50 of 31/153 nM, respectively.
BAY-069 is highly selective for BCAT1/2, and shows no activity against aspartate transaminases (GOT1 and GOT2, glutamate-oxaloacetate transaminase, IC50>50 μM), also is inactive against an protease panel (30 proteases) and kinase panel (30 kinases).
BAY-069 increases cellular branched-chain amino acid (BCAA) in tumor cell lines (U-87 MG and MDA-MB-231) with IC50 of 358 and 874 nM, respectively.
BAY-069 does not inhibit cell proliferation of U-87 MG (high BCAT1 expression) and MDA-MB-231 (high BCAT2 expression) cells.
BAY-069 is a valuable tool to better understand the biology and pharmacology of BCAT inhibition in the field of tumor metabolism.

Physicochemical Properties

M.Wt 446.810
Formula C22H14ClF3N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(4-chloro-3-(o-tolyloxy)naphthalen-1-yl)-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

References

1. Judith Günther, et al. J Med Chem. 2022 Oct 19. doi: 10.1021/acs.jmedchem.2c00441.

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