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S9-A13

Chemical Structure : S9-A13

CAS No.: 1223771-84-3

S9-A13 (S 9-A13)

Catalog No.: PC-49386Not For Human Use, Lab Use Only.

S9-A13 is a highly potent and specific inhibitor of SLC26A9, potently inhibits SLC26A9-mediated Cl−/I− and Cl−/SCN− exchange activities with IC50 of 90.9 and 171.5 nM, respectively.

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    Biological Activity

    S9-A13 is a highly potent and specific inhibitor of SLC26A9, potently inhibits SLC26A9-mediated Cl−/I− and Cl−/SCN− exchange activities with IC50 of 90.9 and 171.5 nM, respectively.
    S9-A13 does not inhibit other members of the SLC26 family and has no effects on Cl− channels such as CFTR, TMEM16A, or VRAC.
    S9-A13 (0-1 uM ) inhibits SLC26A9 currents in a dose-dependent manner in HEK293 cells, but shows little effects on CFTR currents in HEK293 cells at the highest concentration (5 uM).
    S9-A13 has a minor effect on ion transport in human airway epithelial cells and mouse trachea, despite clear expression of SLC26A9 in the apical membrane of ciliated cells.

    Physicochemical Properties

    M.Wt 399.893
    Formula C20H18ClN3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(3-chloro-4-methylphenyl)-3-methyl-4-(5-methylthiophene-2-carbonyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one

    References

    1. Sungwoo Jo, et al. FASEB J. 2022 Nov;36(11):e22534.

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