Catalog No.: PC-49359Not For Human Use, Lab Use Only.
PXS-4748 (PXS4748) is a potent, selective and irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 2.0 uM and 3.2/0.6/1.4/0.2 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
PXS-4748 (PXS4748) is a potent, selective and irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 2.0 uM and 3.2/0.6/1.4/0.2 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
PXS-4787 dose-dependently inhibits lysyl oxidases with IC50 values ranging from 0.2 µM (LOXL4) to 3 µM (LOXL1) and displays comparable inhibitory activity across species.
PXS-4787 selectivity targets lysyl oxidases and is neither an inhibitor of, nor a substrate for, related oxidases.
PXS-4787 (0-10 uM) reduces collagen formation, deposition and crosslinking in primary human dermal fibroblasts cultured in vitro.
PXS-4748 effectively target extracellular LOX without impacting on skin cell phenotype or leading to a compensatory response.
Physicochemical Properties
M.Wt
229.269
Formula
C10H12FNO2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(Z)-3-fluoro-4-(phenylsulfonyl)but-2-en-1-amine
References
1. Chaudhari N, et al. Nat Commun. 2022 Sep 22;13(1):5555.
