Compound 797780-71-3

Chemical Structure : Compound 797780-71-3

Catalog No.: PC-22173Not For Human Use, Lab Use Only.

Compound 797780-71-3 is a small molevcule, covalent inhibitor of DJ-1 (PARK7), effectively inhibits the proliferation of ACHN cells with IC50 of 12.18 uM, inhibits the Wnt signaling pathway.

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Biological Activity

Compound 797780-71-3 is a small molevcule, covalent inhibitor of DJ-1 (PARK7), effectively inhibits the proliferation of ACHN cells with IC50 of 12.18 uM, inhibits the Wnt signaling pathway.
Compound 797780-71-3 demonstrates potent binding affinity in both noncovalent and covalent docking for DJ-1.
Compound 797780-71-3 (20 uM) completely inhibits the levels of β-catenin and the phosphorylation of GSK3β in ACHN cells.

Physicochemical Properties

M.Wt	301.73
Formula	C16H12ClNO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(2-chlorophenoxy)ethyl)indoline-2,3-dione

References

1. Yanyu Ma, et al. Future Med Chem. 2024 Apr;16(7):665-677.

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