OU749 is a potent, species-specific inhibitor of human gamma-glutamyl transpeptidase (GGT) with Ki of 17.6 uM. OU749 is a competitive inhibitor of the acceptor glycyl-glycine, occupies the acceptor site while binding to the gamma-glutamyl substrate complex. OU749 is more than 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 is species-specific, inhibiting GGT isolated from human kidney with 7-10-fold greater potency than GGT isolated from rat or mouse kidney. OU749 does not inhibit GGT from pig cells.
