RSMI-29 | Ricin inhibitor | Probechem Biochemicals

Chemical Structure : RSMI-29

RSMI-29 (RSMI 29)

Catalog No.: PC-22182Not For Human Use, Lab Use Only.

RSMI-29 is a small molecule inhibitor of ricin toxin, specifically targeting ricin toxin A chain (RTA) with binding KD of 0.9 uM, inhibits cytotoxicity of RTA/ricin.

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Biological Activity

RSMI-29 is a small molecule inhibitor of ricin toxin, specifically targeting ricin toxin A chain (RTA) with binding KD of 0.9 uM, inhibits cytotoxicity of RTA/ricin.
RSMI-29 attenuates RTA/ricin-induced protein synthesis inhibition and rRNA depurination.
RSMI-29 (0.15 mg/kg) protects mice against ricin intoxication, reduces ricin-induced organ damage.

Physicochemical Properties

M.Wt	367.38
Formula	C14H17N5O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-diethyl-3-(2-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)hydrazineyl)benzenesulfonamide

References

1. Xinran Yang, et al. Molecules. 2024 Mar 22;29(7):1435.

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RSMI-29 (RSMI 29)

Biological Activity

Physicochemical Properties

References

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