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Chemical Structure : MO-I-1151
Catalog No.: PC-22163Not For Human Use, Lab Use Only.
MO-I-1151 is a second-generation small molecule inhibitor of aspartate β-hydroxylase (ASPH), inhibits cholangiocarcinoma (CCA) cell proliferation and migration.
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MO-I-1151 is a second-generation small molecule inhibitor of aspartate β-hydroxylase (ASPH), inhibits cholangiocarcinoma (CCA) cell proliferation and migration.
MO-I-1151 demonstrated more potent inhibitory effects compared to the parent compound MO-I-1100 (Cat# PC-49471).
MO-I-1151 suppressed colony formation in soft agar and CSC sphere formation in H1 CCA cells, and enhanced caspase-3 cleavage.
MO-I-1151 (25 mg/kg, i.p. every other day for 14 days) substantially delayed tumor growth and progression in rat intrahepatic CCA model.
| M.Wt | 413.37 | |
| Formula | C18H14F3NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chiung-Kuei Huang, et al. PLoS One. 2016 Mar 8;11(3):e0150336.
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