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MO-I-1151

Chemical Structure : MO-I-1151

CAS No.: 1585218-30-9

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MO-I-1151

Catalog No.: PC-22163Not For Human Use, Lab Use Only.

MO-I-1151 is a second-generation small molecule inhibitor of aspartate β-hydroxylase (ASPH), inhibits cholangiocarcinoma (CCA) cell proliferation and migration.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MO-I-1151 is a second-generation small molecule inhibitor of aspartate β-hydroxylase (ASPH), inhibits cholangiocarcinoma (CCA) cell proliferation and migration.
MO-I-1151 demonstrated more potent inhibitory effects compared to the parent compound MO-I-1100 (Cat# PC-49471).
MO-I-1151 suppressed colony formation in soft agar and CSC sphere formation in H1 CCA cells, and enhanced caspase-3 cleavage.
MO-I-1151 (25 mg/kg, i.p. every other day for 14 days) substantially delayed tumor growth and progression in rat intrahepatic CCA model.

Physicochemical Properties

M.Wt 413.37
Formula C18H14F3NO5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-amino-4-oxo-5-(4-(trifluoromethyl)phenyl)-4,5-dihydrofuran-3-yl phenylmethanesulfonate

References

1. Chiung-Kuei Huang, et al. PLoS One. 2016 Mar 8;11(3):e0150336.

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