Catalog No.: PC-22171Not For Human Use, Lab Use Only.
DJ-1 inhibitor comp-23 is a small molecule binding to DJ-1 (PARK7) with binding constant (Kd) of 0.1 uM, exerts a neuroprotective effect by reducing ROS-mediated neuronal injury.
DJ-1 inhibitor comp-23 is a small molecule binding to DJ-1 (PARK7) with binding constant (Kd) of 0.1 uM, exerts a neuroprotective effect by reducing ROS-mediated neuronal injury. Comp-23 prevents oxidative stress-induced death of SH-SY5Y cells and primary neuronal cells of the ventral mesencephalon but not that of DJ-1-knockdown SH-SY5Y cells. Comp-23 exerts a neuroprotective effect by reducing ROS-mediated neuronal injury Comp-23 inhibited the production of reactive oxygen species (ROS) induced by oxidative stress and preventsexcess oxidation of DJ-1. Comp-23 prevented dopaminergic cell death in the substantia nigra and restored movement abnormality in 6-hydroxyldopamine-injected and rotenone-treated PD model rats and mice. Comp-23 also reduces infarct size of cerebral ischemia in rats that had been induced by middle cerebral artery occlusion.
