Catalog No.: PC-21363Not For Human Use, Lab Use Only.
IGF2BP3 inhibitor AE-848 is a small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), inhibits the growth and progression of OC cells by disrupting the stability of the targeted mRNAs of IGF2BP3.
IGF2BP3 inhibitor AE-848 is a small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), inhibits the growth and progression of OC cells by disrupting the stability of the targeted mRNAs of IGF2BP3.
AE-848 significantly inhibited tumor growth by reducing the expression of tumor-associated antigen (c-MYC/VEGF/Ki67/CDK2) and improving the anti-tumor effect of macrophages.
AE-848 not only could duplicate the above results of knockdown assay but also reduces the expression of c-MYC in M2 macrophages and tumor-associated macrophages and promotes the cytokine IFN-γ and TNF-α secretion.
