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PXS-5505 dihydrochloride monohydrate

Chemical Structure : PXS-5505 dihydrochloride monohydrate

CAS No.: 2414974-55-1

PXS-5505 dihydrochloride monohydrate (PXS5505 dihydrochloride monohydrate)

Catalog No.: PC-21385Not For Human Use, Lab Use Only.

PXS-5505 dihydrochloride monohydrate is an orally available, small-molecule, irreversible inhibitor of all lysyl oxidases (pan-LOX) family members, with potential antifibrotic activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PXS-5505 dihydrochloride monohydrate is an orally available, small-molecule, irreversible inhibitor of all lysyl oxidases (pan-LOX) family members, with potential antifibrotic activity.
PXS-5505 inhibited lysyl oxidase activity in the skin and LOXL2 activity in the lung.
PXS-5505 exhibited anti-fibrotic effects in the SSc skin mouse model, reducing dermal thickness and α-smooth muscle actin.
PXS-5505 reduced pulmonary fibrosis toward normal levels in bleomycin-induced mouse lung models.
PXS-5505 also reduced fibrotic extent in models of the ischaemia-reperfusion heart, the unilateral ureteral obstruction kidney, and the CCl4-induced fibrotic liver.

Physicochemical Properties

M.Wt 371.25
Formula C13H17Cl2FN2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-3-fluoro-4-(quinolin-8-ylsulfonyl)but-2-en-1-amine dihydrochloride hydrate

References

1. Yimin Yao, et al. Int J Mol Sci. 2022 May 16;23(10):5533.

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