Chemical Structure : AVJ16
CAS No.:
AVJ16
(IGF2BP1 inhibitor AVJ 16)
Catalog No.: PC-21375Not For Human Use, Lab Use Only.
AVJ16 is a specific and potent IGF2BP1 inhibitor, inhibits H1299 wound healing with IC50 of 0.7 uM, interacts with recombinant IGF2BP1 protein with KD of 1.4 uM in MST assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AVJ16 is a specific and potent IGF2BP1 inhibitor, inhibits H1299 wound healing with IC50 of 0.7 uM, interacts with recombinant IGF2BP1 protein with KD of 1.4 uM in MST assays.
AVJ16 is 14 times more effective than 7773 (Cat#PC-20553).
AVJ16 interacts with IGF2BP1 KH34 di-domain.
AVJ16 (1.5 uM, 48 h) downregulates Kras and other IGF2BP1 target RNAs, Kras RNA and protein in H1299 cells.
AVJ16 inhibits tumorigenic properties of cancer cells in IGF2BP1-dependent manner, does not affect cell growth in LKR-M-GFP cells that do not express IGF2BP1.
Physicochemical Properties
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M.Wt
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469.54
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Formula
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C28H27N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(4-(Benzo[d] [1,3]dioxol-5-yl)piperazin-1-yl) (4-((3-(hydroxymethyl)-1H-indol-1-yl) methyl)phenyl)methanone
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References
1. Singh A, et al. Eur J Med Chem. 2023 Nov 10;263:115940.
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