Chemical Structure : IP-DNQ
CAS No.:
1430798-23-4
IP-DNQ
(Isopentyl-deoxynboquinone)
Catalog No.: PC-21350Not For Human Use, Lab Use Only.
IP-DNQ (Isopentyl-deoxynboquinone) is a small molecule that selectively kills pancreatic ductal adenocarcinoma cells in an NQO1-dependent manner.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IP-DNQ (Isopentyl-deoxynboquinone) is a small molecule that selectively kills pancreatic ductal adenocarcinoma cells in an NQO1-dependent manner.
IP-DNQ evokes massive ROS production and oxidative DNA lesions that results in PARP1 hyperactivation, mitochondrial catastrophe and G2/M-phase arrest, leading to apoptotic and necrotic programmed cell death.
IP-DNQ treatment causes mild methemoglobinemia in vivo, with a three-fold improvement in the maximum tolerated dose compared to DNQ, while significantly suppresses tumor growth and extends the lifespan of mice in subcutaneous and orthotopic pancreatic cancer xenograft models.
Physicochemical Properties
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M.Wt
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340.38
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Formula
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C19H20N2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-isopentyl-4,6-dimethylpyrido[3,2-g]quinoline-2,5,8,10(1H,9H)-tetraone
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References
1. Lingxiang Jiang, et al. Antioxid Redox Signal. 2023 Nov 11. doi: 10.1089/ars.2022.0224.
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