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Karyostatin 1A

Chemical Structure : Karyostatin 1A

CAS No.: 1246468-20-1

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Karyostatin 1A

Catalog No.: PC-21347Not For Human Use, Lab Use Only.

Karyostatin 1A is a small molecule inhibitor of importin beta with binding affinity (Kd=0.3 uM), selectively inhibits the importin α/β pathway.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Karyostatin 1A is a small molecule inhibitor of importin beta with binding affinity (Kd=0.3 uM), selectively inhibits the importin α/β pathway.
Karyostatin 1A specifically inhibit importin α/β mediated nuclear import in living cells.
Karyostatin 1A disrupts the binding of importin β to RanGTP.

Physicochemical Properties

M.Wt 971.22
Formula C53H70N12O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N2-[[2-Methyl-1-(2-methylpropyl)-5-[2-(1-piperidinyl)acetyl]-1H-pyrrol-3-yl]carbonyl]-L-arginyl-N-[3-[[4-[1-[4-[(methylamino)carbonyl]phenyl]-1H-indazol-3-yl]benzoyl]amino]propyl]-N2-propylglycinamide

References

1. Martin Hintersteiner, et al. ACS Chem Biol. 2010 Oct 15;5(10):967-79.

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