ARC39

Chemical Structure : ARC39

Catalog No.: PC-23808Not For Human Use, Lab Use Only.

ARC39 is a direct, selective acid sphingomyelinase (ASM) inhibitor with IO50 of 20 nM, inhibits both lysosomal and secretory ASM in vitro.

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Biological Activity

ARC39 is a direct, selective acid sphingomyelinase (ASM) inhibitor with IO50 of 20 nM, inhibits both lysosomal and secretory ASM in vitro.
ARC39 dose- and time-dependently inhibits lysosomal ASM in intact cells.
ARC39 inhibits platelet- and ASM-promoted adhesion of tumor cells.

Physicochemical Properties

M.Wt	317.26
Formula	C10H25NO6P2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-aminodecylidene bis-phosphonic acid

References

1. McVey MJ, et al. Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L625-L637.

2. Naser E, et al. J Lipid Res. 2020 Jun;61(6):896-910.

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ARC39

Biological Activity

Physicochemical Properties

References

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