Chemical Structure : BL001
CAS No.:
916817-62-4
BL001
Catalog No.: PC-23783Not For Human Use, Lab Use Only.
BL001 is a specific small molecule agonist of liver receptor homologue-1 (LRH-1) with EC50 of 0.1 uM, specifically binds to and activates LRH-1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BL001 is a specific small molecule agonist of liver receptor homologue-1 (LRH-1) with EC50 of 0.1 uM, specifically binds to and activates LRH-1.
BL001 improves islet survival and blunts development of diabetes diabetes in mice.
BL001 decreases insulitis and modulates the blood cytokine profile.
BL001 promotes a pancreatic anti-inflammatory/tolerogenic environment.
BL001 promotes beta and alpha cell mass expansion in immunized RIP-B7.1 mice.
BL001 protects human islets against apoptosis and rescues insulin secretion in islets of type 2 diabetic donors.
Physicochemical Properties
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M.Wt
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415.62
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Formula
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C29H37NO
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3a(1H)-Pentalenamine, 2,3,6,6a-tetrahydro-4-(3-methoxyphenyl)-N-phenyl-5-[(1E)-1-propyl-1-penten-1-yl]-, (3aR,6aS)-rel-
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References
1. Cobo-Vuilleumier N, et al. Nat Commun. 2018 Apr 16;9(1):1488.
2. Martin Vázquez E, et al. iScience. 2022 May 2;25(5):104345.
3. Whitby RJ, et al. J Med Chem. 2006 Nov 16;49(23):6652-5.
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