Chemical Structure : KK181N1
CAS No.:
KK181N1
Catalog No.: PC-23793Not For Human Use, Lab Use Only.
KK181N1 is a specific inhibitor of karrikins (KARs) receptor KAI2, selectively depresses the KAR-induced phenotypes in Arabidopsis, binds to the catalytic pocket of AtKAI2 with Kd of 27.7 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KK181N1 is a specific inhibitor of karrikins (KARs) receptor KAI2, selectively depresses the KAR-induced phenotypes in Arabidopsis, binds to the catalytic pocket of AtKAI2 with Kd of 27.7 uM.
KK181N1 restored the KAR2-induced inhibition of hypocotyl elongation in a concentration-dependent manner up to 10 µM in wild-type seedlings, showed inhibitory effect on hypocotyl growth at 30 µM or higher.
KK181N1 binds to the catalytic pockets of KAI2 in a non-covalent binding manner.
KK181N1 showed highly selective inhibitory activity against KARs signaling without disturbing SLs signaling.
Physicochemical Properties
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M.Wt
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228.26
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Formula
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C12H12N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(7-methylindolin-1-yl)(1H-1,2,3-triazol-1-yl)methanone
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References
1. Wang J, et al. Nat Commun. 2025 Jan 2;16(1):104.
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