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KK181N1

Chemical Structure : KK181N1

CAS No.:

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KK181N1

Catalog No.: PC-23793Not For Human Use, Lab Use Only.

KK181N1 is a specific inhibitor of karrikins (KARs) receptor KAI2, selectively depresses the KAR-induced phenotypes in Arabidopsis, binds to the catalytic pocket of AtKAI2 with Kd of 27.7 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KK181N1 is a specific inhibitor of karrikins (KARs) receptor KAI2, selectively depresses the KAR-induced phenotypes in Arabidopsis, binds to the catalytic pocket of AtKAI2 with Kd of 27.7 uM.
KK181N1 restored the KAR2-induced inhibition of hypocotyl elongation in a concentration-dependent manner up to 10 µM in wild-type seedlings, showed inhibitory effect on hypocotyl growth at 30 µM or higher.
KK181N1 binds to the catalytic pockets of KAI2 in a non-covalent binding manner.
KK181N1 showed highly selective inhibitory activity against KARs signaling without disturbing SLs signaling.

Physicochemical Properties

M.Wt 228.26
Formula C12H12N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(7-methylindolin-1-yl)(1H-1,2,3-triazol-1-yl)methanone

References

1. Wang J, et al. Nat Commun. 2025 Jan 2;16(1):104.

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