Chemical Structure : LFHP-1c
CAS No.:
2102347-47-5
LFHP-1c
Catalog No.: PC-23800Not For Human Use, Lab Use Only.
LFHP-1c is a direct phosphoglycerate mutase family member 5 (PGAM5) inhibitor with binding SPR KD of 961 nM, not only inhibits the PGAM5 phosphatase activity, but also reduces the interaction of PGAM5 with NRF2.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LFHP-1c is a direct phosphoglycerate mutase family member 5 (PGAM5) inhibitor with binding SPR KD of 961 nM, not only inhibits the PGAM5 phosphatase activity, but also reduces the interaction of PGAM5 with NRF2.
LFHP-1c dose-dependently protects rat brains against ischemia/reperfusion injury.
LFHP-1c prevents BBB disruption and attenuates endothelial inflammation in rat cerebral microvessels.
LFHP-1c prevents brain microvascular endothelial cells injury under OGD/R condition.
LFHP-1c targets PGAM5 to facilitate nuclear translocation of NRF2 for endothelial protection in stroke.
LFHP-1c ameliorates brain ischemic injury in tMCAO model of M. fascicularis through PGAM5–NRF2 axis.
Physicochemical Properties
|
M.Wt
|
873.16
|
|
Formula
|
C55H64N6O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
1-(2-((8-(4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxamido)octyl)carbamoyl)phenyl)pentyl acetate
|
References
1. Gao C, et al. Acta Pharm Sin B. 2021 Jul;11(7):1867-1884.
Contact Us
sales@probechem.com
