Chemical Structure : LFHP-1c
CAS No.:
2102347-47-5
LFHP-1c
Catalog No.: PC-23800Not For Human Use, Lab Use Only.
LFHP-1c is a direct phosphoglycerate mutase family member 5 (PGAM5) inhibitor with binding SPR KD of 961 nM, not only inhibits the PGAM5 phosphatase activity, but also reduces the interaction of PGAM5 with NRF2.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LFHP-1c is a direct phosphoglycerate mutase family member 5 (PGAM5) inhibitor with binding SPR KD of 961 nM, not only inhibits the PGAM5 phosphatase activity, but also reduces the interaction of PGAM5 with NRF2.
LFHP-1c dose-dependently protects rat brains against ischemia/reperfusion injury.
LFHP-1c prevents BBB disruption and attenuates endothelial inflammation in rat cerebral microvessels.
LFHP-1c prevents brain microvascular endothelial cells injury under OGD/R condition.
LFHP-1c targets PGAM5 to facilitate nuclear translocation of NRF2 for endothelial protection in stroke.
LFHP-1c ameliorates brain ischemic injury in tMCAO model of M. fascicularis through PGAM5–NRF2 axis.
Physicochemical Properties
|
M.Wt
|
873.16
|
|
Formula
|
C55H64N6O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
1-(2-((8-(4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxamido)octyl)carbamoyl)phenyl)pentyl acetate
|
References
1. Gao C, et al. Acta Pharm Sin B. 2021 Jul;11(7):1867-1884.
Contact Us
sales@probechem.com
