Catalog No.: PC-35479Not For Human Use, Lab Use Only.
Padsevonil (UCB0942) is an antiepileptic drug (AED) candidate with high affinity for synaptic vesicle 2 (SV2) proteins with pKi of 8.5/7.9/8.5 for SV2A/SV2B/SV2C, respectively.
Padsevonil (UCB0942) is an antiepileptic drug (AED) candidate with high affinity for synaptic vesicle 2 (SV2) proteins with pKi of 8.5/7.9/8.5 for SV2A/SV2B/SV2C, respectively.
Padsevonil (UCB0942) displayed low to moderate affinity (pIC50≤6.1) for the benzodiazepine site of recombinant GABAA receptors.
Padsevonil (UCB0942) exhibited SV2A occupancy at low ED50 (0.2 mg/kg) and benzodiazepine site occupancy at higher doses (ED50 36 mg/kg) in in vivo (mice) receptor occupancy studies.
Padsevonil (UCB0942) is a first-in-class AED candidate with a unique target profile allowing for presynaptic and postsynaptic activity.
