Catalog No.: PC-35500Not For Human Use, Lab Use Only.
NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM.
NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM.
NMac1 binds to the C-terminal of Nm23-H1 and induces the NDPK activation through its allosteric conformational changes.
NMac1-treated MDA-MB-231 breast cancer cells showed dramatic changes in morphology and actin-cytoskeletal organization following inhibition of Rac1 activation.
NMac1 also suppressed invasion and migration in vitro, and metastasis in vivo, in a breast cancer mouse model.
