CFM-4.16 is a CARP-1 functional mimetic (CFM) compound binding with CARP-1, stimulates CARP-1 expression and apoptosis.
CFM-4.16 attenuates the activation of STAT3, a transducer of signaling following activation of the EGFR and Src TKs.
CFM-4.16 robustly inhibits oncogenic intracellular kinase Akt activity and/or expression in wild-type HCC 827, H1975 and H23 NSCLC cells.
CFM-4.16 also inhibited Akt activation in erlotinib and gemcitabine-resistant, but not in osimertinib-resistant, NSCLC cells.
CFM-4.16 causes superior inhibition of viability of TNBC cells when used in combination with doxorubicin.
