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CFM-4.16

Chemical Structure : CFM-4.16

CAS No.: 1426415-28-2

CFM-4.16 (CFM4.16)

Catalog No.: PC-35499Not For Human Use, Lab Use Only.

CFM-4.16 is a CARP-1 functional mimetic (CFM) compound bind with CARP-1, stimulates CARP-1 expression and apoptosis.

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    Biological Activity

    CFM-4.16 is a CARP-1 functional mimetic (CFM) compound binding with CARP-1, stimulates CARP-1 expression and apoptosis.
    CFM-4.16 attenuates the activation of STAT3, a transducer of signaling following activation of the EGFR and Src TKs.
    CFM-4.16 robustly inhibits oncogenic intracellular kinase Akt activity and/or expression in wild-type HCC 827, H1975 and H23 NSCLC cells.
    CFM-4.16 also inhibited Akt activation in erlotinib and gemcitabine-resistant, but not in osimertinib-resistant, NSCLC cells.
    CFM-4.16 causes superior inhibition of viability of TNBC cells when used in combination with doxorubicin.

    Physicochemical Properties

    M.Wt 440.342
    Formula C22H15Cl2N3OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(2-chlorobenzyl)-5'-(3-chlorophenyl)-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one

    References

    1. Cheriyan VT, et al. Oncotarget. 2018 Jul 3;9(51):29680-29697.

    2. Cheriyan VT, et al. Oncotarget. 2016 Nov 8;7(45):73370-73388.

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