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Chemical Structure : Soticlestat
CAS No.: 1429505-03-2
Catalog No.: PC-35466Not For Human Use, Lab Use Only.
Soticlestat (TAK-935) is a potent, selective, orally active inhibitor for Cholesterol 24-hydroxylase (CH24H) with IC50 of 7.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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Soticlestat (TAK-935) is a potent, selective, orally active inhibitor for Cholesterol 24-hydroxylase (CH24H) with IC50 of 7.4 nM.
Soticlestat (TAK-935) shows negligible inhibition not only for CYP3A4 (IC50=66 000 nM), but also for other CYP enzymes related to drug metabolism (2C8, 2C9, 2D6, 1A2, 2C19).
Soticlestat (TAK-935) showed dose-dependent reduction in 24HC levels in the brain and exhibited significant reduction at 24 h after single-dose administration to mice (33% reduction at 10 mg/kg and 25% reduction at 3 mg/kg from control level, po).
| M.Wt | 373.456 | |
| Formula | C23H23N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4-benzyl-4-hydroxypiperidin-1-yl)([2,4'-bipyridin]-3-yl)methanone |
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1. Koike T, et al. J Med Chem. 2021 Aug 26;64(16):12228-12244.
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