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Soticlestat

Chemical Structure : Soticlestat

CAS No.: 1429505-03-2

Soticlestat (TAK-935, TAK935, OV935)

Catalog No.: PC-35466Not For Human Use, Lab Use Only.

Soticlestat (TAK-935) is a potent, selective, orally active inhibitor for Cholesterol 24-hydroxylase (CH24H) with IC50 of 7.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Soticlestat (TAK-935) is a potent, selective, orally active inhibitor for Cholesterol 24-hydroxylase (CH24H) with IC50 of 7.4 nM.
Soticlestat (TAK-935) shows negligible inhibition not only for CYP3A4 (IC50=66 000 nM), but also for other CYP enzymes related to drug metabolism (2C8, 2C9, 2D6, 1A2, 2C19).
Soticlestat (TAK-935) showed dose-dependent reduction in 24HC levels in the brain and exhibited significant reduction at 24 h after single-dose administration to mice (33% reduction at 10 mg/kg and 25% reduction at 3 mg/kg from control level, po).

Physicochemical Properties

M.Wt 373.456
Formula C23H23N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(4-benzyl-4-hydroxypiperidin-1-yl)([2,4'-bipyridin]-3-yl)methanone

References

1. Koike T, et al. J Med Chem. 2021 Aug 26;64(16):12228-12244.

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