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Chemical Structure : ATR-101 free base
CAS No.: 133825-80-6
Catalog No.: PC-35460Not For Human Use, Lab Use Only.
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.
ATR-101 induces H295R cell apoptosis, causes mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion, caspase-3/7 activation, and membrane permeabilization.
ATR-101 decreases the formation of cholesteryl esters and increases FC levels in H295R adrenocortical carcinoma cells.
ATR-101 inhibits the establishment and impeds the growth of ACC-derived H295R cell xenografts in mice; orally active.
| M.Wt | 421.629 | |
| Formula | C27H39N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(2,6-diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea |
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1. LaPensee CR, et al. Endocrinology. 2016 May;157(5):1775-88.
2. Trivedi BK, et al. J Med Chem. 1994 May 27;37(11):1652-9.
3. Cheng Y, et al. Endocr Relat Cancer. 2016 Apr;23(4):1-19.
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