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MID-1

Chemical Structure : MID-1

CAS No.: 312608-54-1

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MID-1 (ChemBridge5655896 )

Catalog No.: PC-35530Not For Human Use, Lab Use Only.

MID-1 (ChemBridge5655896) is a specific small molecule MG53-IRS-1 interaction disruptor (MID), but not MG53-FAK and-Cav-3 interaction.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $328 In stock
50 mg $528 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MID-1 (ChemBridge5655896) is a specific small molecule MG53-IRS-1 interaction disruptor (MID), but not MG53-FAK and-Cav-3 interaction.
MID-1 increases the IRS-1 protein level in C2C12 myotubes, abrogates MG53-induced IRS-1 ubiquitination and degradation.
MID-1 potentially sensitizes insulin signaling with an elevated level of IRS-1 in skeletal muscle, enhances C2C12 myogenesis.

Physicochemical Properties

M.Wt 293.30
Formula C12H11N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Ethoxy-N-(5-nitrothiazol-2-yl)benzamide

References

1. Lee H, et al. J Biol Chem. 2016 Dec 23;291(52):26627-26635.

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