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Foslinanib sodium

Chemical Structure : Foslinanib sodium

CAS No.: 1256037-62-3

Foslinanib sodium (TRX-818 sodium, CVM-1118 sodium)

Catalog No.: PC-35451Not For Human Use, Lab Use Only.

Foslinanib (TRX-818, CVM-1118) sodium is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1.

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Biological Activity

Foslinanib (TRX-818, CVM-1118) sodium is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1.
Foslinanib (TRX-818, CVM-1118) induces cancer cell apoptosis and inhibits cancer cell proliferation,.
Foslinanib (TRX-818, CVM-1118) also prevents tumor cell VM by blocking the formation of vasculogenic-like tubular structures through an as of yet undetermined mechanism of action.

Physicochemical Properties

M.Wt 393.218
Formula C16H11FNNa2O5P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

sodium (2-(3-fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl)phosphonate

References

1. Lifen Shen, et al. Pathol Oncol Res. 2023 Jun 7:29:1611038.

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