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HOSU-53

Chemical Structure : HOSU-53

CAS No.: 2659233-16-4

HOSU-53 (HOSU53)

Catalog No.: PC-22220Not For Human Use, Lab Use Only.

HOSU-53 is selective and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.95 nM in cell-free human DHODH enzyme inhibition assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HOSU-53 is selective and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.95 nM in cell-free human DHODH enzyme inhibition assays.
HOSU-53 shows relatively similar inhibitory potency across mouse, rat, and dog DHODH enzyme.
HOSU-53 displays little to no activity against a panel of approximately 450 human kinases at 10 μM.
HOSU-53 exhibits potent in vitro antileukemic activity with median IC50 of 120.5 nM, promotes in vitro innate phagocytic function.
HOSU-53 (30 mg/kg) demonstrates in vivo single-agent antileukemic activity, results in superior in vivo outcome using AML disseminated xenograft model.
HOSU-53 demonstrates in vivo synergy with approved targeted AML therapies.

Physicochemical Properties

M.Wt 415.46
Formula C26H22FNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(3'-butoxy-[1,1'-biphenyl]-4-yl)-6-fluoroquinoline-4-carboxylic acid

References

1. Ola A Elgamal, et al. JCI Insight. 2024 Apr 22;9(8):e173646.

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