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Chemical Structure : HOSU-53
Catalog No.: PC-22220Not For Human Use, Lab Use Only.
HOSU-53 is selective and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.95 nM in cell-free human DHODH enzyme inhibition assays.
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HOSU-53 is selective and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.95 nM in cell-free human DHODH enzyme inhibition assays.
HOSU-53 shows relatively similar inhibitory potency across mouse, rat, and dog DHODH enzyme.
HOSU-53 displays little to no activity against a panel of approximately 450 human kinases at 10 μM.
HOSU-53 exhibits potent in vitro antileukemic activity with median IC50 of 120.5 nM, promotes in vitro innate phagocytic function.
HOSU-53 (30 mg/kg) demonstrates in vivo single-agent antileukemic activity, results in superior in vivo outcome using AML disseminated xenograft model.
HOSU-53 demonstrates in vivo synergy with approved targeted AML therapies.
| M.Wt | 415.46 | |
| Formula | C26H22FNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ola A Elgamal, et al. JCI Insight. 2024 Apr 22;9(8):e173646.
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