DEL-S1

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Chemical Structure : DEL-S1

Catalog No.: PC-25105Not For Human Use, Lab Use Only.

DEL-S1 is a first-in-class small molecule that binds to SLIT2 and disrupts its interaction with ROBO1 with IC50 of 68.8 uM in TR-FRET assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DEL-S1 is a first-in-class small molecule that binds to SLIT2 and disrupts its interaction with ROBO1 with IC50 of 68.8 uM in TR-FRET assays.
DEL-S1 impairs SLIT2/ROBO1 complex formation by inducing conformational rearrangements.
DEL-S1 exhibited favorable ADME properties, including satisfactory plasma and microsomal stability, low cytotoxicity, and minimal hERG liability.

Physicochemical Properties

M.Wt	534.67
Formula	C27H38N10O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((4-(4-(2-cyanophenyl)piperazin-1-yl)-6-(cyclohexyl(ethyl)amino)-1,3,5-triazin-2-yl)amino)-N1-methylsuccinamide

References

1. Yuan S, et al. bioRxiv [Preprint]. 2025 Jun 22:2025.06.22.660907.

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DEL-S1

Biological Activity

Physicochemical Properties

References

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