Catalog No.: PC-24626Not For Human Use, Lab Use Only.
RJG-2036 is a potent, selective, covalent prostaglandin reductase 2 (PTGR2) inhibitor with IC50 of 100 nM (human PTGR2), covalently ligands the noncatalytic Y100 and Y265 residues located in the substrate binding pocket.
RJG-2036 is a potent, selective, covalent prostaglandin reductase 2 (PTGR2) inhibitor with IC50 of 100 nM (human PTGR2), covalently ligands the noncatalytic Y100 and Y265 residues located in the substrate binding pocket.
RJG-2036 blocks recombinant PTGR2 biochemical activity with IC50 of 176 nM.
RJG-2036 ligands the noncatalytic Y100 and Y265 sites on PTGR2.
RJG-2036 (10 uM) suppresses LPS-stimulated TNF-α response in THP1 macrophages, alters the activity of PTGR2-regulated eicosanoids.
