Chemical Structure : BPRPT0245
CAS No.:
2982603-10-9
BPRPT0245
Catalog No.: PC-24307Not For Human Use, Lab Use Only.
BPRPT0245 is a specific small-molecule inhibitor of prostaglandin reductase 2 (PTGR2) with IC50 of 8.92 nM, restores 15-keto-PGE2-dependent PPARγ trans-activation in HEK293T cells expressing recombinant PTGR2 with EC50 of 49.22 nM.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BPRPT0245 is a specific small-molecule inhibitor of prostaglandin reductase 2 (PTGR2) with IC50 of 8.92 nM, restores 15-keto-PGE2-dependent PPARγ trans-activation in HEK293T cells expressing recombinant PTGR2 with EC50 of 49.22 nM.
BPRPT0245 not only increased intracellular 15-keto-PGE2 concentrations in a dose-dependent manner but also augmented insulin-stimulated glucose uptake of differentiated 3T3-L1 adipocytes.
BPRPT0245 interferes with the interaction between 15-keto-PGE2 and NADPH within the catalytic site of hPTGR2.
BPRPT0245 protected mice from diet-induced obesity, insulin resistance, glucose intolerance, and fatty liver without fluid retention and reduced bone density.
Physicochemical Properties
|
M.Wt
|
446.53
|
|
Formula
|
C25H27FN6O
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
6-(4-fluorobenzyl)-5-methyl-2-(1-(4-phenylpiperazin-1-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
|
References
1. Chang YC, et al. EMBO Mol Med. 2025 Mar 21. doi: 10.1038/s44321-025-00216-4.
Contact Us
sales@probechem.com
