Chemical Structure : ASS1 inhibitor C-01
CAS No.:
904438-03-5
ASS1 inhibitor C-01
Catalog No.: PC-25222Not For Human Use, Lab Use Only.
ASS1 inhibitor C-01 is a small molecule inhibitor of argininosuccinate synthetase 1 (ASS1), binds to ASS1 directly with SPR Kd of 18.8 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ASS1 inhibitor C-01 is a small molecule inhibitor of argininosuccinate synthetase 1 (ASS1), binds to ASS1 directly with SPR Kd of 18.8 nM.
C-01 occupied the orthosteric sites of ASS1 and formed five hydrogen bonds with Arg157, Lys176, Met181, and Arg272 of ASS1, respectively.
C-01 (100 μM) effectively suppressed the phosphorylation of STAT3 in IL-6-exposed NCM460 cells.
C-01 suppresses the upregulated protein level of COX-2, P-mTOR, P-STAT3 and P-S6 in DSS mice, induces downregulation of arginine levels in both colon tissue and blood.
C-01 significantly alleviates intestinal inflammation in ulcerative colitis (UC) mouse models.
Physicochemical Properties
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M.Wt
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460.55
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Formula
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C23H28N2O6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(5-(N-(4-ethoxyphenyl)-N-propylsulfamoyl)indolin-1-yl)-4-oxobutanoic acid
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References
1. Liu S, et al. Nat Commun. 2025 Jul 30;16(1):6983.
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