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(R)-ABS01-113

Chemical Structure : (R)-ABS01-113

CAS No.:

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(R)-ABS01-113

Catalog No.: PC-49149Not For Human Use, Lab Use Only.

(R)-ABS01-113 is a potent, selective dopamine D3 receptor (D3R) antagonist with IC50 of 11.4 nM, binds with high affinity to D3R with Ki value of 0.34 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (R)-ABS01-113 is a potent, selective dopamine D3 receptor (D3R) antagonist with IC50 of 11.4 nM, binds with high affinity to D3R with Ki value of 0.34 nM.
    (R)-ABS01-113 displays excellent oral bioavailability and high brain penetration.
    Pretreatment with (S)-ABS01-113 attenuated heroin-enhanced hyperactivity, heroin self-administration, and (heroin + cue)-induced reinstatement of drug-seeking behavior in animal models of opioid use disorders (OUD).

    Physicochemical Properties

    M.Wt 456.990
    Formula C25H30ClFN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-(4-(4-(3-chloro-2-ethylphenyl)piperazin-1-yl)-3-fluorobutyl)-1H-indole-2-carboxamide

    References

    1. Ewa Galaj, et al. Neuropsychopharmacology. 2022 Jul 25. doi: 10.1038/s41386-022-01379-1.

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