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(R)-HTS-3

Chemical Structure : (R)-HTS-3

CAS No.: 2771208-83-2

(R)-HTS-3

Catalog No.: PC-38905Not For Human Use, Lab Use Only.

(R)-HTS-3 is a small-molecule inhibitor of LPCAT3, an integral membrane acyltransferase in the Lands cycle responsible for generating C20:4 phospholipids.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (R)-HTS-3 is a small-molecule inhibitor of LPCAT3, an integral membrane acyltransferase in the Lands cycle responsible for generating C20:4 phospholipids.
    (R)-HTS-3 inhibits LPCAT3 in a biphasic manner, possibly reflecting differential activity at each subunit of the LPCAT3 homodimer.
    (R)-HTS-3 treatment cause rapid rewiring of polyunsaturated phospholipids in human cells.
    LPCAT3 has been implicated in key biological processes such as intestinal lipid absorption, lipoprotein assembly, and ferroptosis.

    Physicochemical Properties

    M.Wt 304.34
    Formula C17H18F2N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-N-(2-(dimethylamino)-2-phenylethyl)-3,5-difluorobenzamide

    References

    1. Alex Reed, et al. ACS Chem Biol. 2022 Jun 17;17(6):1607-1618.

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