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(R)-HZ05

Chemical Structure : (R)-HZ05

CAS No.: 2097360-28-4

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(R)-HZ05 (DHODH inhibitor (R)-HZ05)

Catalog No.: PC-63262Not For Human Use, Lab Use Only.

(R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.

    Physicochemical Properties

    M.Wt 380.423
    Formula C21H21FN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,5,6,7-tetrahydrobenzo[c]isoxazole-3-carboxamide

    References

    1. Ladds MJGW, et al. Nat Commun. 2018 Mar 16;9(1):1107.

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