Chemical Structure : (R)-HZ05
Catalog No.: PC-63262Not For Human Use, Lab Use Only.
(R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo..
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(R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.
M.Wt | 380.423 | |
Formula | C21H21FN4O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Ladds MJGW, et al. Nat Commun. 2018 Mar 16;9(1):1107.
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