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(R)-HZ05

Chemical Structure : (R)-HZ05

CAS No.: 2097360-28-4

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(R)-HZ05 (DHODH inhibitor (R)-HZ05)

Catalog No.: PC-63262Not For Human Use, Lab Use Only.

(R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

(R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.

Physicochemical Properties

M.Wt 380.423
Formula C21H21FN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,5,6,7-tetrahydrobenzo[c]isoxazole-3-carboxamide

References

1. Ladds MJGW, et al. Nat Commun. 2018 Mar 16;9(1):1107.

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