(R)-ND-336 | MMP-9 inhibitor | Probechem Biochemicals

Chemical Structure : (R)-ND-336

(R)-ND-336 ((R)-ND336)

Catalog No.: PC-35659Not For Human Use, Lab Use Only.

(R)-ND-336 is a potent and selective small-molecule MMP-9 inhibitor with Ki of 19 nM, weakly inhibits MMP-2 and MMP-14 (Ki=127 and 119 nM), poorly inhibits other MMPs (Ki>10 uM).

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Biological Activity

(R)-ND-336 is a potent and selective small-molecule MMP-9 inhibitor with Ki of 19 nM, weakly inhibits MMP-2 and MMP-14 (Ki=127 and 119 nM), poorly inhibits other MMPs (Ki>10 uM).
(R)-ND-336 demonstrates superior efficacy in wound healing over becaplermin in vivo.

Physicochemical Properties

M.Wt	371.894
Formula	C16H18ClNO3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-(4-(4-((Thiiran-2-ylmethyl)sulfonyl)-phenoxy)phenyl)methanamine hydrochloride

References

1. Nguyen TT, et al. J Med Chem. 2018 Sep 27. doi: 10.1021/acs.jmedchem.8b01005.

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(R)-ND-336 ((R)-ND336)

Biological Activity

Physicochemical Properties

References

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